Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • HIF
    (8)
  • HIF/HIF Prolyl-Hydroxylase
    (4)
  • Apoptosis
    (2)
  • Dehydrogenase
    (1)
  • Endogenous Metabolite
    (1)
  • Guanylate cyclase
    (1)
  • HSP
    (1)
  • Influenza Virus
    (1)
  • Proton pump
    (1)
  • Others
    (13)
Filter
Search Result
Results for "

HIF 1α inhibitor 1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    32
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    4
    TargetMol | Peptide_Products
  • PROTAC Products
    3
    TargetMol | PROTAC
  • Natural Products
    2
    TargetMol | Natural_Products
Indacaterol acetate
T716591000160-96-2
Indacaterol acetate is an ultra-long-acting beta-adrenoceptor agonist.
  • Inquiry Price
8-10 weeks
Size
QTY
HIF-1α inhibitor-1
T716611000025-14-8
HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.
  • Inquiry Price
6-8 weeks
Size
QTY
Verucopeptin
T9649138067-14-8In house
Verucopeptin is a pyranized cyclic peptide and an inhibitor of hypoxia-inducible factor 1 (HIF-1). It is an antibiotic effective against B16 melanoma, with anticancer activity, lowering the expression of HIF-1 target genes and HIF-1α protein levels. It can be used in cancer research.
  • Inquiry Price
Size
QTY
LW6
HIF-1α inhibitor, CAY10585, LW8
T3494934593-90-5
LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.
  • Inquiry Price
Size
QTY
Lificiguat
YC-1
T4381170632-47-0
Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
GN44028
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
T153961421448-26-1
GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. However, It can not be suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α HIF-1β heterodimerization.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
(S,R,S)-AHPC-C5-COOH
VH032-C5-COOH
T186672267282-19-7
(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized conjugate for E3 ligase ligand-linker applications, combining the VH032 VHL-based ligand with a linker for PROTAC development. VH-032 is a selective and potent VHL HIF-1α interaction inhibitor with a dissociation constant (Kd) of 185 nM, offering potential in anemia and ischemic diseases research[1].
  • Inquiry Price
Size
QTY
PX-12
PX12, IV-2
T2283141400-58-0
PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor growth in animal models. Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated as a potential cancer treatment in combination with chemotherapy for patients with advanced metastatic cancer. Initial trials correlated doses of Px-12 with increased patient survival.
  • Inquiry Price
Size
QTY
LXY6090
LXY 6090,LXY-6090
T27866
LXY6090 is a HIF-1 inhibitor. LXY6090 inhibited the activity of HIF-1 and downregulated the protein level of HIF-1α in breast cancer cells. LXY6090 showed in vivo anticancer efficacy by decreasing the HIF-1α expression in nude mice bearing MX-1 tumor xeno
  • Inquiry Price
Size
QTY
Dimethyl-bisphenol A
T603981568-83-8
Dimethyl-bisphenol A (DMBPA) is a potent inhibitor of HIF-1α, promoting its degradation by dissociating Hsp90 from HIF-1α and thus decreasing the expression of Vegfa mRNA [1].
  • Inquiry Price
6-8 weeks
Size
QTY
HIF-IN-1
T604132393928-76-0
HIF-IN-1 is a potent inhibitor of hypoxia-inducible factor (HIF-1), which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.
  • Inquiry Price
7-10 days
Size
QTY
HIF-1α-IN-4
T60524
HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects. HIF-1α-IN-4 downregulates VEGF and PDK1 mRNA expressions under hypoxia [1].
  • Inquiry Price
10-14 weeks
Size
QTY
HIF-1α-IN-5
T60532
HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A. HIF-1α-IN-5 downregulates the mRNA expressions of VEGF and PDK1 under hypoxia. HIF-1α-IN-5 has the potential to be used in the cancer research[1].
  • Inquiry Price
10-14 weeks
Size
QTY
HIF-1α-IN-3
T611612170715-64-5
HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].
  • Inquiry Price
6-8 weeks
Size
QTY
hif-1/2α-in-1
T61442
HIF-1 2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1 2α-IN-1 has the ability to decrease HIF-1α levels. This compound is particularly valuable for research on clear cell renal cell carcinoma (ccRCC) [1].
  • Inquiry Price
10-14 weeks
Size
QTY
Izilendustat hydrochloride
T630351303513-80-5
Izilendustat (hydrochloride) is a potent inhibitor of prolyl hydroxylase that stabilizes hypoxia-inducible factor-1 alpha (HIF-1α) and hypoxia-inducible factor-2 (HIF-2), with potential applications in HIF-1α-related diseases, including peripheral vascular disease (PVD), heart failure, coronary artery disease (CAD), ischaemia, anaemia, colitis, and other inflammatory bowel diseases.
  • Inquiry Price
1-2 weeks
Size
QTY
HIF-1 inhibitor-4
HIF-1 inhibitor-4
T67767333357-56-5
HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level.
  • Inquiry Price
Size
QTY
Chetomin
Chaetomin, NSC289491, BRN0077366
T68041403-36-7
Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
  • Inquiry Price
Size
QTY
GEM-5
T745302233543-49-0
GEM-5, a gemcitabine-based conjugate incorporating a HIF-1α inhibitor (YC-1) (IC 50 =30 nM), notably suppresses HIF-1α expression while enhancing tumor suppressor p53 expression. It induces apoptosis in A2780 cells and curbs tumor growth [1].
  • Inquiry Price
Size
QTY
7-Hydroxyneolamellarin A
T75487959662-26-1
7-Hydroxyneolamellarin A, a natural product from the sponge Dendrilla nigra, serves as a potent inhibitor of hypoxia-inducible factor-1α (HIF-1α). It effectively reduces the accumulation of HIF-1α protein and suppresses vascular epidermal growth factor (VEGF) transcriptional activity, making it valuable in cancer research [1].
  • Inquiry Price
Size
QTY
TAT-cyclo-CLLFVY TFA
T75943
TAT-cyclo-CLLFVY TFA is a cyclic peptide inhibitor targeting HIF-1 heterodimerization to mitigate hypoxia signaling within cancer cells. It effectively disrupts the protein-protein interaction between HIF-1α and HIF-1β, with an inhibitory concentration (IC 50) of 1.3 μM [1].
  • Inquiry Price
Size
QTY
HIF-1α-IN-2 hydrochloride
T78123
HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, with IC50 values of 28 nM in MDA-MB-231 cells and 15 nM in MiaPaCa-2 cells, effectively suppressing HIF-1α expression by inhibiting transcription and protein translation [1].
  • Inquiry Price
Size
QTY
VHL-IN-1
T79720
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and enhances its transcriptional activity. It shows promise for applications as a HIF-1α stabilizer and for the degradation of proteolytically targeted chimeras (PROTACs) [1].
  • Inquiry Price
Size
QTY
HIF-1α-IN-6
T82198
HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α with IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively, and it suppresses HIF-1α expression by reducing HIF-1α mRNA levels [1].
  • Inquiry Price
Size
QTY